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• Brochure: Solutions for pharmaceutical analysis [en]

  Renishaw is a world leader in Raman spectroscopy instrumentation, with over 25 years’ experience supplying Raman systems to customers worldwide. We are a global company, with a worldwide network of scientists and engineers who are on-hand to provide you with expert product, applications and technical support. We understand the many challenges within pharmaceutical analysis and our flexible solutions have been designed with your needs in mind. Whether novice or expert, formulator or quality analyst, we have a system to meet your requirements.

  

  Brochure: Solutions for pharmaceutical analysis

  Renishaw is a world leader in Raman spectroscopy instrumentation, with over 25 years’ experience supplying Raman systems to customers worldwide. We are a global company, with a worldwide network of scientists and engineers who are on-hand to provide you with expert product, applications and technical support. We understand the many challenges within pharmaceutical analysis and our flexible solutions have been designed with your needs in mind. Whether novice or expert, formulator or quality analyst, we have a system to meet your requirements.

  [3.3MB]
• Product note: RA802 Pharmaceutical Analyser [en]

  Designed exclusively for the pharmaceutical industry, the RA802 rapidly obtains detailed information on the distribution of chemical species.

  

  Product note: RA802 Pharmaceutical Analyser

  Designed exclusively for the pharmaceutical industry, the RA802 rapidly obtains detailed information on the distribution of chemical species.

  [395kB]
• Application note: New methods for determining content uniformity of formulations [en]

  Using the RA802 to monitor the uniformity of a drug product’s contents to ensure that the correct dose is delivered every time.

  

  Application note: New methods for determining content uniformity of formulations

  Using the RA802 to monitor the uniformity of a drug product’s contents to ensure that the correct dose is delivered every time.

  [215kB]
• Application note: Study the stability of pharmaceutical formulations with Raman microscopy [en]

  Many pharmaceutical materials are highly sensitive to changes in temperature and humidity which can affect their crystalline structure. Knowing the stability of these polymorphs and hydrates, in different conditions, is critical to ensure products are safe, efficient and can be patent protected.

  

  Application note: Study the stability of pharmaceutical formulations with Raman microscopy

  Many pharmaceutical materials are highly sensitive to changes in temperature and humidity which can affect their crystalline structure. Knowing the stability of these polymorphs and hydrates, in different conditions, is critical to ensure products are safe, efficient and can be patent protected.

  [372kB]
• Application note: Investigate pharmaceutical solid dose products using the inVia confocal Raman microscope [en]

  With so many components and properties, determining the composition, domain size and distribution of patent-expired commercially available formulations is highly desirable. This information creates opportunities to replicate an existing product without the need for lengthy development and prohibitive costs.

  

  Application note: Investigate pharmaceutical solid dose products using the inVia confocal Raman microscope

  With so many components and properties, determining the composition, domain size and distribution of patent-expired commercially available formulations is highly desirable. This information creates opportunities to replicate an existing product without the need for lengthy development and prohibitive costs.

  [412kB]
• Application note: Transmission Raman for monitoring pharmaceuticals [en]

  Whether at the research and development stage, or manufacturing, the inVia Raman microscope offers simple and fast transmission Raman analysis.

  

  Application note: Transmission Raman for monitoring pharmaceuticals

  Whether at the research and development stage, or manufacturing, the inVia Raman microscope offers simple and fast transmission Raman analysis.

  [540kB]
• Application note: Combined chemical and particle distribution analysis of pharmaceutical powders [en]

  When formulating pharmaceuticals, it is important to understand the chemical composition and morphologies of the ingredients, as these can lead to changes in product performance. For example, active ingredient co-localisation and particle adhesion can affect the efficacy of formulation. This application note details how to use a Renishaw Raman system to conduct this type of analysis.

  

  Application note: Combined chemical and particle distribution analysis of pharmaceutical powders

  When formulating pharmaceuticals, it is important to understand the chemical composition and morphologies of the ingredients, as these can lead to changes in product performance. For example, active ingredient co-localisation and particle adhesion can affect the efficacy of formulation. This application note details how to use a Renishaw Raman system to conduct this type of analysis.

  [580kB]
• Application note: Using Raman spectroscopy to tackle polymorphism, an industry problem [en]

  This note looks at incidences of polymorphism in drug development including advantages and challenges.

  

  Application note: Using Raman spectroscopy to tackle polymorphism, an industry problem

  This note looks at incidences of polymorphism in drug development including advantages and challenges.

  [204kB]
• Application note: Raman imaging for deformulating a transdermal patch [en]

  An application note detailing the RA802's ability to deformulate the make-up of a transdermal nicotine patch.

  

  Application note: Raman imaging for deformulating a transdermal patch

  An application note detailing the RA802's ability to deformulate the make-up of a transdermal nicotine patch.

  [872kB]
• Application note: Rapid polymorph identification with the RA802 Pharmaceutical Analyser [en]

  Characterising the polymorphism of active pharmaceutical ingredients when developing a commercially viable product.

  

  Application note: Rapid polymorph identification with the RA802 Pharmaceutical Analyser

  Characterising the polymorphism of active pharmaceutical ingredients when developing a commercially viable product.

  [174kB]
• Technical note: Quantitative Raman spectroscopy [en]

  This document focuses on concentration measurements but the principles detailed are also applicable to other quantitative measurements, such as stress/strain.

  

  Technical note: Quantitative Raman spectroscopy

  This document focuses on concentration measurements but the principles detailed are also applicable to other quantitative measurements, such as stress/strain.

  [453kB]
• White paper: Finding fakes – using Raman imaging to identify counterfeit medicines [en]

  Raman spectroscopy is highly specific and well-suited to identifying counterfeits which often use similar components to the reference product.

  

  White paper: Finding fakes – using Raman imaging to identify counterfeit medicines

  Raman spectroscopy is highly specific and well-suited to identifying counterfeits which often use similar components to the reference product.

  [547kB]
• White paper: Methods for deformulating drugs [en]

  In this white paper we look at reverse engineering existing drug products using Raman imaging. We show that the Renishaw RA802 Pharmaceutical Analyser can be used to successfully characterise innovator and generic products and facilitate deformulation activities, and can characterise the components, concentrations, particle sizes and distributions of the innovator formulation, allowing generic followers to adjust their processes in order to create equivalent products, or products which are strategically different.

  

  White paper: Methods for deformulating drugs

  In this white paper we look at reverse engineering existing drug products using Raman imaging. We show that the Renishaw RA802 Pharmaceutical Analyser can be used to successfully characterise innovator and generic products and facilitate deformulation activities, and can characterise the components, concentrations, particle sizes and distributions of the innovator formulation, allowing generic followers to adjust their processes in order to create equivalent products, or products which are strategically different.

  [1.5MB]
• Technical note: Polymorph identification and qualification [en]

  This technology note illustrates the benefits of combining dedicated analysis software with a high-performance Raman instrument and how Renishaw supplies an effective, user-friendly solution to provide complementary information to the multitude of established HTS techniques commercially available.

  

  Technical note: Polymorph identification and qualification

  This technology note illustrates the benefits of combining dedicated analysis software with a high-performance Raman instrument and how Renishaw supplies an effective, user-friendly solution to provide complementary information to the multitude of established HTS techniques commercially available.

  [552kB]
• Application note: Detecting small amounts of multiple API polymorphic forms in powder blends [en]

  The stability, bioavailability and processability of an active pharmaceutical ingredient (API) are key to a candidate molecule’s ability to be developed into a commercially viable product. Different drug polymorphs can vary markedly in properties such as their flowability, dissolution rate, solubility, and stability. Characterising the different polymorphic forms of a drug and selecting the optimum polymorph for drug product development have become important considerations in this process. Renishaw’s RA802 Pharmaceutical Analyser was used to detect small amounts of different polymorphic forms (form I and form II) of an active pharmaceutical ingredient (API) in a generic drug powder.

  

  Application note: Detecting small amounts of multiple API polymorphic forms in powder blends

  The stability, bioavailability and processability of an active pharmaceutical ingredient (API) are key to a candidate molecule’s ability to be developed into a commercially viable product. Different drug polymorphs can vary markedly in properties such as their flowability, dissolution rate, solubility, and stability. Characterising the different polymorphic forms of a drug and selecting the optimum polymorph for drug product development have become important considerations in this process. Renishaw’s RA802 Pharmaceutical Analyser was used to detect small amounts of different polymorphic forms (form I and form II) of an active pharmaceutical ingredient (API) in a generic drug powder.

  [237kB]